CHAPTER 2 THE POWER OF STEM CELLS
Stem cells, ideally the placenta, are the foundation of the coming wave of regenerative medicine. Panama and Mexico are common destinations for Americans seeking stem cell therapy. In the U.S., Fountain Life (Naples FL) offers many of the diagnostics discussed in the book. If you are interested in learning more about stem cell therapy and the options available to you, visit website for further information.
CHAPTER 3 DIAGNOSTIC POWER: BREAKTHROUGHS THAT CAN SAVE YOUR LIFE
Early detection and precision diagnostics are the key to longevity.
Detecting heart disease: coronary CT angiography (CCTA)
Detecting cancer: blood tests (GRAIL) and whole body MRI
Detecting Alzheimers: brain MRI + AI
Detecting hormones abnormalities: blood tests
Detecting toxic metal accumulation: blood tests
Other diagnostic tests worth doing: DEXA bone density scan, DNA analysis, microbiome analysis, TruAge telomere test
CHAPTER 4 TURNING BACK TIME: WILL AGING SOON BE CURABLE?
David Sinclair’s protocol: limits red meat, avoids sugar, one meal per day, limits alcohol, 8 hours of sleep, exercises 3 days a week, D3+K2, 1g of reservatrol, 1g of NMN.
The epigenetic joystick that controls how the genome functions is more powerful than the genetic code itself.
Sirtuins govern the epigenome, boosting mitochondrial activity, reducing inflammation, and protecting telomeres. Sirtuins direct DNA repair.
How to help Sirtuins? Supplement with NMN to boost NAD+.
CHAPTER 5 THE MIRACLE OF ORGAN REGENERATION
New organ therapies that will save people suffering from organ failures are only a few years ago.
Ex vivo lung perfusion restores unusable lung donations to make them usable.
Human-pig hybrids could be a reliable source of many types of organs.
3D printing will advance to the point that it can produce more organs than just skin and ears
Lymph nodes can be used to grow organs one day.
CHAPTER 6 THE MIGHTY CAR T CELL: A BREAKTHROUGH CURE FOR LEUKEMIA
(Chimeric Antigen Receptor) CAR T cell therapy is a hybrid of gene therapy and immunotherapy that might be a cure for leukemia.
CHAPTER 7 INCISIONLESS BRAIN SURGERY: THE IMPACT OF FOCUSED ULTRASOUND
Focused ultrasound neurosurgery is showing great promise as a therapy for Parkinsons, brain cancers, ALS, depression, and opiod addiction.
CHAPTER 8 GENE THERAPY AND CRISPR: THE CURE FOR DISEASE
CRISPR is an amazing new technology that might make it possible to edit any gene and, thereby, cure many rare, genetic diseases, repair damaged tissue, and prevent Alzheimers.
CHAPTER 9 THE WONDROUS WNT PATHWAY: THE ULTIMATE FOUNTAIN OF YOUTH?
The biotech company Biosplice is manipulating the Wnt pathway to regenerate cells and tissues and heal many lethal cancers.
CHAPTER 10 YOUR ULTIMATE VITALITY PHARMACY
Peptides are short chains of amino acids that regulate cell division and gene expression. 80+ peptides have been approved by the FDA for a numer of diseases. Peptides are also being used to combat the effects of aging. For metabolic health, semaglutide. To strengthen our immune system, thymosin alpha-1. To boost libido and sex, PT-141. To heal the gut, tendons, ligaments, and skin, BPC-157. For muscles and strength, sermorelin and tesamorelin. For skin and hair, GHK-Cu.
Metformin is typically an diabetes drug, but it’s been shown to help regulate mitochondria, boost repair, and help prevent cancer.
Hormone Optimization Therapy, different from HRT, has so many benefits and a few risks that have been overstated in the media.
NAD+ Precursors help boost NAD+ levels. NAD+ is a helper molecule that regulates cell metabolism and longevity genes. David Sinclair supplements with nicotinamide mononucleotide (NMN) daily to battle aging.
Key Neutraceuticals are very beneficial, but only if sourced from high-quality companies. D3, omega-3 fish oil, magnesium, K1/K2, choline, and creatine.
Rapamycin has shown promise as a longevity drug, but more research is still needed.
CHAPTER 11 LIVING PAIN-FREE
Pulsed electromagnetic field therapy (PEMF) uses electromagnetic fields to reduce pain, stimulate healing, and decrease inflammation.
Postural therapies, such as Egoscue and Counterstrain, can reduce chronic pain through improved biomechanics.
Virtual reality shows the potential of mind over body when it comes to pain perception.
Laser therapies, like the Genesis One laser, can stimulate healing.
Stem cells are probably still the go-to therapy for chronic pain relief.
Instead of opiods, hospitals should consider Toradol for pain relief.
Ombi is an app that uses cognitive behavioral therapy (CBT) to treat substance abuse and addiction.
Acupuncture has been used for thousands of years to treat pain and there is good scientific evidence to support its use.
CHAPTER 12 THE LONGEVITY LIFESTYLE & DIET
The root cause of most chronic diseases is poor lifestyle choices, which lead to metabolic, cellular, genetic damage, and then chronic disease.
Studies show that lifestyle choices (exercise) can lengthen telomeres.
Stay away from sugars and refined carbs.
Diet genomes respond differently to different diets.
Eat whole foods. Eat more greens and vegetables, particularly cruciferous vegetables which contain sulfurophane.
Dr. Valter Longo created the Longevity and Lifestyle Diet, which promotes a plant-based diet with fish 2-3 times per week.
Micheal Pollan summarizes a healthy diet in seven words. “Eat food. Not too much. Mostly plants.”
Intermittent fasting improves longevity.
The 5 day fasting mimicking diet can be an alternative to a strict fast, with many of the same benefits.
Most adults need to drink about 3 liters of water per day. Consider adding lemon and Celtic salt to your water.
Improve your health by focusing on your breathing. Read Breathwalk. Practice Navy SEAL box breathing.
Many chronic diseases can be helped or cured by optimizing your gut microbiome. Company mentioned: Viome.
Genetic testing can help guide what diets might work best for you.
Frequent sauna users are 40% less likely to die from all causes of premature death. Companies: Health Mate Sauna, Almost Heaven Sauna.
Cold plunges and cryotherapy sessions help in recovery and healing. Companies: TheColdPlunge.com.
CHAPTER 13 THE POWER OF SLEEP: THE THIRD PILLAR OF HEALTH
Sleep is likely even more important to longevity and health than diet and exercise.
If you have sleep apnea, lose weight, get a CPAP, or get a mandibular advancement device (MAD).
Stick to a good sleep schedule and a regular get-ready-for-bed routine.
Use a ChiliPad to sleep at 65 degrees.
Avoid devices before bed.
Use an Oura ring to track your sleep.
CHAPTER 14 STRENGTH, FITNESS & PERFORMANCE: YOUR QUICK GUIDE TO MAXIMUM RESULTS
Exercise is a miracle cure for most preventable diseases.
Walking is great. Jogging is better.
Muscle mass is a new vital sign we should all try to improve.
Using a walking desk is better than sitting all day.
OsteoStrong is a training regiment that claims to build muscle strength and bone density in 10 minutes, once per week, by using the principle of static contraction.
Start strength training with these four exercises, everyday for 10 minutes: squats, lunges, pushups, planks.
A Whoop strap can monitor stress and recovery for you.
Use a BackBridge to decompress and realign your spine.
VR fitness devices motivate you to exercise by turning it into a game. Mentioned: Thrill of the Fight, Ocululs, Supernatural VR.
CHAPTER 15 BEAUTY: ENHANCING YOUR VISIBLE HEALTH & VITALITY
In many ways, our skin is a reflection of our health.
At the Harklinikken clinic, clients experience increases in hair volume and mass, through changes to your environment and habits, including a reduction of stress, and with the right mix of root-plant extracts and proteins, fatty acids, and cow’s milk.
There are at least a dozen companies attacking hair loss using biotech, such as stem cells and 3D printing.
Newest therapies for skin and face rejuvenation: stem cells, cryofacials, and lasers.
Clinics are freezing away stubborn bodyfat, using tools like CoolSculpting. Clinics are also using radiofrequency waves to burn away fat, using tools like Thermage, and Vanquish.
The cosmetics industry is starting to use AI, your skin traits, and your DNA to personalize cosmetic products.
OneSkin includes a proprietary peptide in its OS1 product meant to rejuvenate skin.
CHAPTER 16 WOMEN’S HEALTH: THE CYCLE OF LIFE
Women who go through menopause later in life tend to have a longer overall lifespan.
Even though women live statistically longer than men, they spend more of their lives in poor health (thirty-four years on average) compared to men (twenty-six years).
Menopause happens when the ovaries cease functioning because they have run out of eggs. 10 percent of women are infertile by the time they turn 35, but thanks to technology, nearly 20 percent of births are to women over the age of 35.
There is considerable variability when it comes to the menstrual cycle.
The only other creatures that go through menopause are a few species of whale. No one knows exactly why women’s ovaries shut down the processes of menstruation and ovulation.
Gather as much baseline data about YOUR BODY and YOUR UNIQUE CYCLE as possible so that you know what your “normal” is, using the menstrual cycle as a vital sign, and multiple apps (MyFLO, Clue, Ovia, Period Tracker, Glow).
Sleep. Move. Don’t consume overly processed foods. Eat your greens. Choose organic when you can. Rest and digest. For heaven’s sake don’t smoke. Limit or eliminate alcohol. Limit or eliminate stress. Know that if you choose to ingest dairy products from cow’s milk, you’re choosing to ingest hormones and common allergens. Drink plenty of water. Keep your blood sugar balanced. Steer clear of artificial sweeteners. Get rid of the toxins in cleaning products, detergents, body care, and personal items like aluminum deodorants and aerosol sprays.
Supplements to consider: calcium, iodine, zinc, B-complex vitamins, magnesium.
HRT can reduce the overall health risks associated with menopause and can also ease the symptoms that so dramatically impact a woman’s quality of life.
Other novel therapies on the horizon: laser, platelet rich plasma (PRP).
CHAPTER 17 HOW TO MEND A BROKEN HEART
Heart disease is the number one killer of Americans.
Caladrius Biosciences is working on using CD34+ stem cells to repair the damage caused by a heart attack.
Elevian is using Growth Differentiation Factor 11 (GDF11) to rejunevate aging hearts and brains.
CorMatrix invented a patch made from a patient’s stem cells that can be stitched over damaged heart tissue.
VentriGel is injecting a hydrogel to heal damaged heart tissue.
The heart is the least regenerative organ in the human body. Heart attacks lead to scarring which leads to more problems.
Scientists at Sana Biotechnology are seeing success injecting stem cells to regenerate damaged heart tissue.
Scientists at the Texas Heart Institute are able to regrow a ghost heart on top of a dead heart scaffold.
Rejuvenate Bio is working on gene therapy to cure age-related diseases in dogs.
CHAPTER 18 YOUR BRAIN: TREATING STROKES
TPA is the only FDA-approved treatment for strokes caused by clots.
Robotic gloves help stroke survivors regain motion.
Virtual reality helps to improve stroke survivors’ dexterity and mobility.
Elevian has developed a naturally occurring protein called growth differentiation factor 11 (GDF11) with powerful regenerative properties. GDF11 can repair and reverse ischemic stroke symptoms.
Openwater is using red laser light and holography to measure the brain blood flow of a patient, in the ambulance.
We could use VR to retrain the nervous system to function again.
Transcranial rotating permanent magnetic stimulation (TRPMS) restores functional activity to damaged brain tissue — up to sixteen years after stroke.
CHAPTER 19 HOW TO WIN THE WAR ON CANCER
A high-performing immune system is one of the most important ways to defend against cancer, and virtually all diseases.
A simple blood test that can detect up to fifty kinds of cancer at their earliest and most treatable stage .
There’s no better diagnostic tool than the newest forms of whole-body MRI.
Scientists regard inflammation as a key culprit in aging and specifically in cancer .
We use peptides to boost immunity by boosting T cells. T cells and their progeny, natural killer cells — which are also known as NK cells — circulate looking for tumor cells.
Excessive visceral fat raises the risk of a wide array of nasty illnesses that you’ll be delighted to avoid, including colorectal cancer, breast cancer, heart disease, and type 2 diabetes.
The most effective things you can do to avoid illness and enhance your vitality is to sleep eight hours per night, minimize your sugar intake, and exercise regularly, with a special emphasis on building muscle strength.
Strength training can also arrest cognitive decline.
GRAIL has developed a liquid biopsy — a simple blood test that is able to detect most major types of cancer at an early stage. Galleri costs $949.
Freenome can provide an easy, affordable, laxative-free test for colorectal cancer.
Sulforaphane in broccoli sprouts can slam the brakes on tumor growth
The immune system can eliminate cancer.
Future cancer treatments that use the immune system: checkpoint inhibitors, personalized cancer vaccines, natural killer cells, tumor-infiltrating lymphocytes that multiply a patient’s T cells to fight solid tumors, cancer-fighting exosomes.
Get yourself tested, ideally with a full-body MRI and the GRAIL blood test. Find a location near you, or you’re welcome to contact Fountain Life.
CHAPTER 20 CONQUERING INFLAMMATION AND AUTOIMMUNE DISEASE: BRINGING PEACE TO THE BODY
Where does autoimmune disease come from? Infections, toxic chemicals in the environment, heavy metals, and ultraviolet radiation.
Chronic inflammation activates your immune system into a state of wartime readiness for months or years at a time.
Your bone marrow contains a homegrown pantry of non-steroidal , anti-inflammatory medicines. We know them as stem cells. In the fight against autoimmune disease, early evidence suggests that all these cells may need is some reinforcement.
TPE has already been proven to help patients with autoimmune diseases like myasthenia gravis and Guillain-Barre syndrome, or those with relapses of multiple sclerosis.
TPE slowed the cognitive decline of Alzheimer’s patients by 66 percent.
Neutrolis has created a molecular scissors that cuts up free-floating DNA to significantly lower inflammation.
Eat green leafy vegetables, brightly colored vegetables, fatty fish (wild salmon, mackerel), most fruits, nuts and seeds, green tea.
CHAPTER 21 DIABETES AND OBESITY: DEFEATING A DOUBLE THREAT
Track waist circumference, waist-to-hip ratio, skinfold thickness, and DEXA scans for bone density.
Researchers now associate ultra – processed foods — often loaded with sugar , salt , fat , and calories — with an increased risk of type 2 diabetes , hypertension , and cardiovascular disease .
What not to eat? Refined carbohydrates (white flour, white bread, and pasta.)
Radically reduce your intake of sugar.
Healthy fats can actually help to stabilize your blood sugar.
Slow carbs (brown rice, quinoa, farro, and steel-cut oats) can be a key component of a healthy diet.
CHAPTER 22 ALZHEIMER’S DISEASE: ERADICATING THE BEAST
A simple blood test that can predict Alzheimer’s years before symptoms.
Marvel Biome that is harnessing the power of the microbiome to fight neurodegeneration.
Vaxxinity’s vaccine every three to six months may train your immune system to fight Alzheimer’s.
A stack of psychedelic mushroom + lion’s mane shows healing effects on neurodegenerative diseases like Alzheimer’s.
Get enough sleep to naturally purge amyloid.
Social interaction cuts Alzheimer’s risk by twofold.
A mutant form of the gene CD33 can protect people from Alzheimer’s.
Exercise actually induces neurogenesis.
Intellectual stimulation can actually cause new synapses to form.
Arethusta is neurosurgical Roto – Rooter, intended to be a safe and simple shunt that can be implanted through the nose.
One of the most powerful things you can do to head off dementia is to use a hearing aid, if you need one.
Learning a new language or practicing the piano seems to confer real benefits.
Some of the most effective anti-dementia tools around may be specialized video games devised by elite neuroscientists.
Hyperbaric oxygen therapy (HBOT) has been shown to be the most effective therapy for traumatic brain injury.
CHAPTER 23 LONGEVITY AND THE POWER OF EXPONENTIAL TECHNOLOGIES (BY PETER H. DIAMANDIS, MD)
The day before something is truly a breakthrough, it’s a crazy idea.
If you can’t win, change the rules.
The average age of early humans was only about 28 years old .
Longevity escape velocity is the notion that in the near future, science will be able to extend your life by more than a year for every year you are alive.
To paraphrase Ray Kurzweil, it means we need to strive to “live long enough to live forever.”
Every single person will have the ability for real-time monitoring of their health and physiology from sensors in their body and on their body, measuring everything from blood glucose and blood pressure, to microRNAs that might indicate an impending heart attack, or the quality of their sleep.
If AI we could accurately predict protein structures from an amino acid sequence, it would open the door to an entire new avenue of low-cost and accurate drug development. AI could generate novel drugs to target any disease, overnight.
Imagine remote-controlled microbots, smaller than a grain of rice, that travel through the body to deliver drug treatments to precise locations.
While our linear human mind is great at making near – term predictions , we vastly underestimate what can be achieved in the longer term .
If we don’t extend health life and productive healthspan we are likely to face a significant shortage of labor.
Slowing aging by only one year is worth + $ 38 trillion to the global economy .
Imagine that someone goes for a treatment that uses three of the four Yamanaka Factors to epigenetically reprogram their body.
It’s quite possible that some of us in this conversation today will be seeing 150 or 200 years.
CHAPTER 24 CREATING AN EXTRAORDINARY QUALITY OF LIFE: THE POWER OF MINDSET
The placebo effect is a fascinating example of your mindset at work.
Simply changing your outlook can add years to your life!
Positive attitudes protect against dementia.
Fear was more deadly for COVID patients.
The science of psychoneuroimmunology, or PNI, the study of how what we think (psycho) changes the brain (neuro) and in turn affects our immune system.
Where you live emotionally determines what your life is really like .
Decision #1: What should I FOCUS on?
Decision #2: What does this MEAN?
Decision #3: What am I going to DO?
Once we start taking 100 percent responsibility for our experience of life rather than blaming others, we can awaken to a truth that makes all the difference: whatever life offers us, we get to decide what to focus on what it means and what we’re going to do about it.
CHAPTER 25 THE POWER OF DECISION: THE GIFT OF LIVING IN A BEAUTIFUL STATE
Extraordinary people like Oprah, Nelson Mandela, and Viktor Frankl, against all odds created life on their terms.
It’s not our conditions, but our decisions that determine the quality of our lives.
Extreme stress is going to be a given in your life. So the real key to have an extraordinary quality of life to develop the kind of psychological and emotional strength that makes you resilient.
Some people let disappointment destroy them, while others let it drive them — that’s a choice.
The most important decision that you can make is to decide that life is too short to suffer and that you’re going to appreciate and enjoy this gift of life, no matter what happens.
Trade your expectations for appreciation and in that moment, your whole life will change.
Find a way to appreciate whatever life gives you.
Energy medicine (aka tapping) is a scientific antidote to stress.
Use priming ot wire yourself for a peak state.